Gliclazide is a novel antidiabetic drug of 2nd generation in sulfonylurea group which is classified under BCS Class II. It is characterized by low solubility in gastric fluid, low dissolution rate and inter-individual variability in bioavailability. The objective of this study was to design solid dispersions (SD) of Gliclazide with a hydrophilic carrier viz., Kollidon VA 64 by hot melt extrusion method in an attempt to enhance the aqueous solubility and therapeutic efficacy of the drug. The absorption rate of gliclazide was increased from upper part to lower part of GIT and from jejunum to descending colon which has pH-dependent solubility, drug with complexing agent to increase the solubility of gliclazide and pH-independent release patterns were assigned.Solid dispersions were prepared by using Kollidon VA 64 as carriers, in different drug-to-carrier ratios (1:1, 1:2, 1:3, 1:4) by hot melt extrusion . These formulations were subjected to solubility, dissolution study and were characterized for solid state properties by differential scanning calorimetry (DSC). The optimized solid dispersion (1:4) was characterized for solid state properties by powder X-ray powder diffraction (PXRD) and Fourier Transform Infrared (FTIR) spectral studies. Solid-state characterization revealed the conversion of Gliclazide from crystalline to amorphous form in the formulation (1:4) with Kollidon VA 64. The aqueous solubility and dissolution rate of Gliclazide in solid dispersion was greatly improved when compared to pure form. Solid dispersions also showed efficient wetability and dispersability than pure drug.
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